Cigarette Harm Reduction

Our primary mission in tobacco is to reduce the harm caused by smoking. Our VLN® reduced nicotine content tobacco cigarettes – containing 95% less nicotine than conventional cigarettes – help adult smokers in the U.S. and international markets reduce their nicotine intake.


Our VLN® King and VLN® Menthol King cigarettes are the world’s first and only combustible cigarettes to receive Modified Risk Tobacco Product (MRTP) authorization from the U.S. Food and Drug Administration (FDA). In granting this designation, the Agency established that VLN® cigarettes – which smoke, taste, and smell like conventional cigarettes– “help reduce exposure to, and consumption of, nicotine for smokers who use them.”


The FDA’s MRTP authorization officially recognizes the key features of our VLN® cigarettes:

  • VLN® helps reduce smoking frequency and duration

  • VLN® contains 95% less nicotine

  • VLN® helps reduce nicotine consumption

  • VLN® can greatly reduce nicotine consumption


VLN® cigarettes are made with 22nd Century Group’s U.S. grown tobacco. Our specially developed tobacco has 95% less nicotine than “Big Tobacco’s” standard high-nicotine tobacco. For decades, “Big Tobacco” has intentionally manipulated, formulated, created, and marketed products that create and sustain nicotine addiction. 22nd Century has collaborated with world-class scientists to develop a product that does the exact opposite.


Containing just 0.5 mg of nicotine per gram of tobacco, VLN® is the only combustible tobacco product that meets the low nicotine levels proposed in the FDA’s Advance Notice of Proposed Rulemaking (ANPRM). This proposed FDA ruling requires all combustible cigarettes to contain “minimally or non-addictive” levels of nicotine.

The FDA believes that such a nicotine cap, as part of its Comprehensive Plan for Tobacco and Nicotine Regulation, would help five million adult smokers to quit within one year, help 33 million people to avoid becoming regular smokers, and prevent more than eight million smoking-related American deaths by the end of the century. The beneficial impact of this action on smokers and public health overall cannot be overstated.

Numerous independent scientific studies, funded largely by the FDA, the National Institutes of Health, and other U.S. federal government agencies, have demonstrated that using reduced nicotine content tobacco cigarettes helps smokers reduce their nicotine exposure and dependence, smoke fewer cigarettes per day, increase their number of smoke-free days, and double their attempts to quit – all with minimal or no evidence of nicotine withdrawal or compensatory smoking behavior. VLN® helps people smoke less.

22nd Century remains committed to licensing its reduced nicotine content technology and products to every tobacco manufacturer, thereby, enabling industry-wide compliance with the FDA’s proposed nicotine caps. 22nd Century also remains committed to licensing its reduced nicotine content technology and products to other international partners for the benefit of global public health.

For the latest information on VLN® King and VLN® Menthol King, visit


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